A clinical research study is medical research to learn more about investigational drugs or unapproved new drugs. Clinical research studies help us understand the safety and effectiveness of the investigational drug being researched.

Participants have different reasons for participating in clinical research, including:

• Contributing to the advancement of science.
• Gaining access to investigational drugs or study procedures that otherwise would be unavailable options.

You will first go through a screening process at the study site. If you are eligible for the Cervino Study, you will be randomly assigned (like the flip of a coin) to receive one of the following treatment options:

• ABBV-383 alone, OR
• One of the following standard available therapies, as decided by your study doctor:
  • carfilzomib + dexamethasone (Kd)
  • elotuzumab + pomalidomide + dexamethasone (EloPd)
  • selinexor + bortezomib + dexamethasone (SVd)

A member of the study team will be in touch with you every 4 weeks for about 1 year after study completion to see how you are doing and ask some questions about your health. After that first year, the follow up will occur less frequently, about every 12 weeks thereafter.

Participants are expected to attend all clinic visits and complete all study procedures according to the study doctor’s instructions to ensure we can understand how the treatment is working. You may receive reimbursement for study-related travel related expenses. The study team can provide more details if you do qualify and are considering participation.

Your participation in the study is voluntary—you can stop participating at any time for any reason without any penalty or loss of benefits to which you may otherwise be entitled.